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KMID : 0613820110210060811
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Journal of Life Science
2011 Volume.21 No. 6 p.811 ~ p.818
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Inhibitory Effects of Maesaengi (Capsosiphon fulvescens) Extracts on Angiotensin Converting Enzyme and α-Glucosidase
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Cho Eun-Kyung
Yoo Seul-ki
Choi Young-Ju
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Abstract
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Physiological activities of hot water (MHW) and 80% ethanol (MEH) extracts from Maesaengi (Capsosiphon fulvescens) were investigated in this study. For the evaluation of antioxidant activities for MHW and MEH, 2,2-diphenyl-1-pic-rylhydrazyl (DPPH) radical scavenging activity and superoxide dismutase (SOD)-like activity were measured. DPPH radical scavenging activity and SOD-like activity of MHW, and MEH were increased weekly in a dose-dependent manner, and were about 10.8, 13.8, 62.4, and 27.1% at 10 ㎎/㎖, respectively. The angiotensin converting enzyme (ACE) inhibitory activities of MHW and MEH were about 5.9% and 49.7% at 1 ㎎/㎖, respectively. The α-glucosidase inhibitory effect of MHW and MEH were about 1.4% and 67.3% at 1 ㎎/㎖, respectively. To determine the influence of MHW and MEH on alcohol metabolizing activity, the generating activities of reduced-nicotinamide adenine dinucleotide (NADH) by alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) were measured. Facilitating rates of ADH activity by MHW and MEH were increased weekly in a dose-dependent manner and ALDH activities were not detected. Elastase inhibitory activities of MHW and MEH were 75.9% and 51.2% at 10 ㎎/㎖, respectively.
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KEYWORD
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Maesaengi, antioxidant activity, angiotensin converting enzyme, α-glucosidase, alcohol metabolizing activity, elastase
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